The effect of dexmedetomidine on the firing properties of STN neurons in Parkinson's disease.
Identifieur interne : 000504 ( Main/Exploration ); précédent : 000503; suivant : 000505The effect of dexmedetomidine on the firing properties of STN neurons in Parkinson's disease.
Auteurs : Vibhor Krishna [Canada] ; Gavin Elias [Canada] ; Francesco Sammartino [Canada] ; Diellor Basha [Canada] ; Nicolas K K. King [Canada] ; Alfonso Fasano [Canada] ; Renato Munhoz [Canada] ; Suneil K. Kalia [Canada] ; Mojgan Hodaie [Canada] ; Lashmi Venkatraghavan [Canada] ; Andres M. Lozano [Canada] ; William D. Hutchison [Canada]Source :
- The European journal of neuroscience [ 1460-9568 ] ; 2015.
English descriptors
- KwdEn :
- Action Potentials (drug effects), Analgesics, Non-Narcotic (pharmacology), Deep Brain Stimulation (methods), Dexmedetomidine (pharmacology), Dose-Response Relationship, Drug, Female, Humans, Male, Microelectrodes, Middle Aged, Neurons (drug effects), Parkinson Disease (pathology), Parkinson Disease (therapy), Statistics, Nonparametric, Subthalamic Nucleus (cytology), Subthalamic Nucleus (physiology).
- MESH :
- chemical , pharmacology : Analgesics, Non-Narcotic, Dexmedetomidine.
- cytology : Subthalamic Nucleus.
- drug effects : Action Potentials, Neurons.
- methods : Deep Brain Stimulation.
- pathology : Parkinson Disease.
- physiology : Subthalamic Nucleus.
- therapy : Parkinson Disease.
- Dose-Response Relationship, Drug, Female, Humans, Male, Microelectrodes, Middle Aged, Statistics, Nonparametric.
Abstract
Dexmedetomidine (an alpha-2 adrenergic agonist) sedation is commonly used during subthalamic nucleus (STN) deep-brain stimulation (DBS). Its effects on the electrophysiological characteristics of human STN neurons are largely unknown. We hypothesised that dexmedetomidine modulates the firing rates and bursting of human STN neurons. We analysed microelectrode recording (MER) data from patients with Parkinson's disease who underwent STN DBS. A 'Dex bolus' group (dexmedetomidine bolus prior to MER; 27 cells from seven patients) was compared with a 'no sedation' group (29 cells from 11 patients). We also performed within-patient comparisons with varying dexmedetomidine states. Cells were classified as dorsal half or ventral half based on their relative location in the STN. Neuronal burst and oscillation characteristics were analysed using the Kaneoke-Vitek methodology and local field potential (LFP) oscillatory activity was also investigated. Dexmedetomidine was associated with a slight increase in firing rate (41.1 ± 9.9 vs. 34.5 ± 10.6 Hz, P = 0.02) but a significant decrease in burstiness (number of bursts, P = 0.02; burst index, P < 0.001; percentage of spikes in burst, P = 0.002) of dorsal but not ventral STN neurons. This was not associated with modulation of beta oscillations in the spike-oscillations analysis(beta peak, P = 0.4; signal-to-noise ratio in the beta range for spikes and bursts, P = 0.3 and P = 0.5, respectively) and LFP analysis (Beta power, P = 0.17). As bursting pattern is often used to identify STN and guide electrode placement, we recommend that high-dose dexmedetomidine should be avoided during DBS surgery.
DOI: 10.1111/ejn.13004
PubMed: 26108432
Affiliations:
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Le document en format XML
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<author><name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
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<author><name sortKey="Munhoz, Renato" sort="Munhoz, Renato" uniqKey="Munhoz R" first="Renato" last="Munhoz">Renato Munhoz</name>
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<author><name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K" last="Kalia">Suneil K. Kalia</name>
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<author><name sortKey="Venkatraghavan, Lashmi" sort="Venkatraghavan, Lashmi" uniqKey="Venkatraghavan L" first="Lashmi" last="Venkatraghavan">Lashmi Venkatraghavan</name>
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<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
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<author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Action Potentials (drug effects)</term>
<term>Analgesics, Non-Narcotic (pharmacology)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Dexmedetomidine (pharmacology)</term>
<term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
<term>Neurons (drug effects)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Statistics, Nonparametric</term>
<term>Subthalamic Nucleus (cytology)</term>
<term>Subthalamic Nucleus (physiology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Analgesics, Non-Narcotic</term>
<term>Dexmedetomidine</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Action Potentials</term>
<term>Neurons</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Dose-Response Relationship, Drug</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Microelectrodes</term>
<term>Middle Aged</term>
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<front><div type="abstract" xml:lang="en">Dexmedetomidine (an alpha-2 adrenergic agonist) sedation is commonly used during subthalamic nucleus (STN) deep-brain stimulation (DBS). Its effects on the electrophysiological characteristics of human STN neurons are largely unknown. We hypothesised that dexmedetomidine modulates the firing rates and bursting of human STN neurons. We analysed microelectrode recording (MER) data from patients with Parkinson's disease who underwent STN DBS. A 'Dex bolus' group (dexmedetomidine bolus prior to MER; 27 cells from seven patients) was compared with a 'no sedation' group (29 cells from 11 patients). We also performed within-patient comparisons with varying dexmedetomidine states. Cells were classified as dorsal half or ventral half based on their relative location in the STN. Neuronal burst and oscillation characteristics were analysed using the Kaneoke-Vitek methodology and local field potential (LFP) oscillatory activity was also investigated. Dexmedetomidine was associated with a slight increase in firing rate (41.1 ± 9.9 vs. 34.5 ± 10.6 Hz, P = 0.02) but a significant decrease in burstiness (number of bursts, P = 0.02; burst index, P < 0.001; percentage of spikes in burst, P = 0.002) of dorsal but not ventral STN neurons. This was not associated with modulation of beta oscillations in the spike-oscillations analysis(beta peak, P = 0.4; signal-to-noise ratio in the beta range for spikes and bursts, P = 0.3 and P = 0.5, respectively) and LFP analysis (Beta power, P = 0.17). As bursting pattern is often used to identify STN and guide electrode placement, we recommend that high-dose dexmedetomidine should be avoided during DBS surgery.</div>
</front>
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</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Ontario"><name sortKey="Krishna, Vibhor" sort="Krishna, Vibhor" uniqKey="Krishna V" first="Vibhor" last="Krishna">Vibhor Krishna</name>
</region>
<name sortKey="Basha, Diellor" sort="Basha, Diellor" uniqKey="Basha D" first="Diellor" last="Basha">Diellor Basha</name>
<name sortKey="Elias, Gavin" sort="Elias, Gavin" uniqKey="Elias G" first="Gavin" last="Elias">Gavin Elias</name>
<name sortKey="Fasano, Alfonso" sort="Fasano, Alfonso" uniqKey="Fasano A" first="Alfonso" last="Fasano">Alfonso Fasano</name>
<name sortKey="Hodaie, Mojgan" sort="Hodaie, Mojgan" uniqKey="Hodaie M" first="Mojgan" last="Hodaie">Mojgan Hodaie</name>
<name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name>
<name sortKey="Kalia, Suneil K" sort="Kalia, Suneil K" uniqKey="Kalia S" first="Suneil K" last="Kalia">Suneil K. Kalia</name>
<name sortKey="King, Nicolas K K" sort="King, Nicolas K K" uniqKey="King N" first="Nicolas K K" last="King">Nicolas K K. King</name>
<name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
<name sortKey="Munhoz, Renato" sort="Munhoz, Renato" uniqKey="Munhoz R" first="Renato" last="Munhoz">Renato Munhoz</name>
<name sortKey="Sammartino, Francesco" sort="Sammartino, Francesco" uniqKey="Sammartino F" first="Francesco" last="Sammartino">Francesco Sammartino</name>
<name sortKey="Venkatraghavan, Lashmi" sort="Venkatraghavan, Lashmi" uniqKey="Venkatraghavan L" first="Lashmi" last="Venkatraghavan">Lashmi Venkatraghavan</name>
</country>
</tree>
</affiliations>
</record>
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